Ncentral giant cell granuloma of the jaws pdf

Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. The lesion was histopathologically diagnosed as central giant cell granuloma. The clinical behavior of cgcg of the jaws is variable and difficult to predict. An aggressive central giant cell granuloma in a pediatric patient. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and peripheral ossifying fibroma. Traditional treatment has been local curettage, although aggressive subtypes have a high tendency to recur. The most common treatment is curettage,which has a high recurrence rate, particularly in more. To determine the demographic, clinical and radiographic features of the central giant cell granulomas cgcg of jaws. Central giant cell granuloma of the jaws and giant cell tumor of long bones are wellrecognized entities revealing benign nature 16. Giant cell tumors and pseudogiant cell tumors of the jaws are divided into cherubism, central giant cell granuloma cgcg, aneurysmal cyst, giant cell tumor, and hyperparathyroidismjaw tumor. Intralesional corticosteroid injection for central giant cell granuloma.

Case report giant cell tumor of the maxilla in an 8 year old boy sabhlok s1. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. Management of central giant cell granulomas of the jaws. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. Uses microscopic slides and shows postops of 1,4,and 7 months. Central giant cell granuloma of the mandible american. Central giant cell granuloma is a benign intraosseous lesion. The incidence in the general population is very low and patients are generally younger than 30 years. The neoplastic status of the central giant cell granuloma of the jaws remains an unsolved contro versy in anatomic pathology.

This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. Case report giant cell granuloma of the maxilla usman haider uzbek, iram mushtaq oral and maxillofacial unit, department of dentistry, ayub medical college, abbottabad. From 2002 to 2008, we surgically treated 8 cases of giant cell granuloma. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells.

This patient report describes a recurrent central giant cell granuloma involving the body of the mandible in a 48yearoldwoman. The radiolucency is most likely the microscopic appearance of the central giant cell granuloma of the jaws is similar to that of lesions which occur in for which of the following pathological conditions would a lower central incisor tooth be expected to respond to heat, cold and electric pulp test. By continuing to use our website, you are agreeing to our use of cookies. Full text pimary hyperparathyroidism as central giant cell. Gcrg is an uncommon benign lesion that is most commonly found in the mandible and maxilla. The lesion was removed by curettage and a histopathological examination was carried out. The term central giant cell lesion has been proposed as a microscopic feature and not those of a true granulomatous process. Central giant cell granuloma of the jaws and giant cell. A clinicopathological, cytometric and immunohistochemical comparative study manal a al sheddi 1, hezekiah a mosadomi 2, fh al dayel 3. Pimary hyperparathyroidism as central giant cell granuloma of the jaws. Due to these lesions often being symptomatic, active management is usua. Central giant cell granuloma of the maxilla bmj case reports.

Cgcg is described as a benign lesion affecting the mandible and maxilla that consists of a massive fibrohistiocytic prolife ration. Odontogenic tumors and giant cell lesions of jaws a nine. Central giant cell granuloma and fibrous dysplasia occurring. Incision was followed by blunt dissection with preservation of the facial nerve. Central giant cell granuloma is considered widely to be nonneo. The central giant cell reparative granuloma of the jaws. Because of its overwhelming incidence on the gingiva, the condition is associated with two other diseases, pyogenic granuloma and. Interventions for central giant cell granuloma of the jaws. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. Based on clinical, radiological, and histopathological findings provisional diagnosis of central giant cell granuloma was made. In addition, differentiating between aggressive and nonaggressive central giant cell granuloma cgcg of the jaws based on histopathologic features is still impossible and due to different treatment protocols for the two groups, correct diagnosis is necessary. This observational study was conducted at outpatient department of oral and dental hospital, khyber college of dentistry peshawar and private clinics at peshawar, nowshera, mardan and kohat, from june 2006 to may 2018. Central giant cell granuloma cgcg is defined by the world health organization as an intraosseous lesion consisting of cellular fibrous tissue that contains multiple foci of haemorrhage, aggregations of multiple nucleated giant cells, and occasionally trabeculae of woven bone.

It was jaffe who first introduced the term central giant cell reparative granuloma to distinguish this lesion from the giant cell tumor of long bones. It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. Jul 29, 2009 shows preop considerations, the operative removal, and properties of the giant cell granuloma. Of 16 giant cell lesions localized in the mandible, 12 75% were found in the. Central giant cell reparative granuloma of the jaws. Their clinical behavior 8,29, prognostic factors and the histogenesis have been subject of several studies. Intralesional corticosteroid injection for central giant cell. Clinicalpathological considerations and report of a case. Cgcg is the most common giant cell lesion of the jaws. Giant cell granulomas are benign intraosseous lesions, typically occurring in young females.

Central giant cell granuloma cgcg of the jaw bones is a rare benign intraosseous lesions that is commonly seen as indolent lesions in the mandible anterior to the first molar. Radiologic features of central giant cell granuloma of the jaws. Multiple recurrent central giant cell granulomas of the jaws. Central giant cell granuloma cgcg is a benign intraosseous lesion of unknown etiology, and occurs in jaws. Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 1530 nuclei. An aggressive central giant cell granuloma in a pediatric. These lesions are localised fibrous tissue tumours which contain osteoclasts and are usually several centimetres across. The term giant cell reparative granuloma gcrg was first used by jaffe in 1953, to distinguish these lesions from giant cell tumor of long bones. A retrospective analysis of a 20year database was performed regarding both clinical and radiological features of 22 patients affected with cgcgs of the jaws. The aim of this study was to compare cgcg of the jaws and gct of long bones from clinicopathology, cytometry and immunohistochemistry aspects. Central giant cell granuloma of the mandible youtube. Interventions for central giant cell granuloma of the jaws the central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. Bilateral central giant cell connecting repositories. Harris m 1993 central giant cell granulomas of the jaws regress with calcitonin therapy.

It is uncommon 7% of all benign jaw lesions, and the biologic behaviour ranges from quiescent to. Oct 19, 2015 we report the results of the intralesional steroid injections for the management of central giant cell granuloma cgcg of the jaws. Central giant cell granuloma of the jaws and giant cell tumor of long bones. Genetic profiling of central giant cell granuloma of the jaws. Aggressive central giant cell granuloma of the mandible, a. It is an uncommon, benign and proliferative non neoplastic process. A case of a 31yearold caucasian female with multiple recurrent central giant cell granulomas of the maxilla and mandible is presented. Radiological and epidemiological aspects of central giant cell. Management of central giant cell granuloma of the jaws with. Peripheral giantcell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. Hence, this study was designed to provide a demographic data on the odontogenic tumors and giant cell lesions reported from. Three years later she noticed a similar nodule in the lower right posterior region of jaw which was again surgically excised and histopathologically diagnosed as central giant cell granuloma.

The histopathological diagnosis was central giant cell granuloma. The objective was to investigate the clinical and radiological characteristics of central giant cell granulomas cgcgs of the jaws. Correlation between vascularity and biologic behavior saede atarbashi moghadam1, maedeh ghorbanpour2 1 assistant professor, department of oral and maxillofacial pathology, school of dentistry, shahid beheshti university of medical sciences, tehran, iran. This is in contrast to the giant cell tumor of long bones, where the giant cells are more evenly distributed. Central giant cell granuloma of the jaws and giant cell tumor of long bones are wellrecognized entities revealing benign nature16. Initially they were thought to be related to teeth in some way, although they were not considered completely odontogenic in origin. Differential diagnosis has to be made with other osteolytic neoformations of the jaws, both unicystic and multicystic odontogenic tumors, fibrous dysplasia, cysts, etc. The etiology and clinical behaviour of giant cell lesions are still debatable. It is a localized osteolytic lesion with the varied biologic behavior of aggression which affects the jaw bones. Central giant cell granuloma of the jaws springerlink. Abstract central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. Central giant cell granulomas of the condyle are rare.

The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was. The central giant cell granuloma cgcg is an uncommon benign bony lesion that accounts for less than 7% of all benign lesions of the jaws in toothbearing areas. The microscopic appearance of the central giant cell. Central giant cell granuloma cgcg is a benign lesion of bone of variably aggressive nature that was first described by jaffe1.

The diagnosis and management of giant cell lesions of the jaws. Interventions for central giant cell granuloma cgcg of. Central giant cell granuloma cgcg or giant cell lesions are reported commonly in females and in first two decades of life. Central giant cell granuloma cgcg is a benign lesion of the jaws with an unknown etiology. Despite this, a recurrence rate of 1520% is often quoted, and in these cases treatment may need to be more aggressive and may need to consist of an en bloc resection.

Pdf central giant cell granuloma is an uncommon, benign, and proliferative lesion whose. The central giant cell granuloma cgcg of the jaws is a rare benign tumour of the mandible lower jaw and the maxilla upper jaw characterized by destruction of the bone, loss of symmetry of the face and displacement of teeth and tooth germs, especially in younger patients. Central giant cell granuloma cgcg is an uncommon, benign but aggressive osteolytic neoplasm of the craniomaxillofacial region, histologically characterized by an abundance of evenly distributed multinucleated giant cells within a sea of spindleshaped mesenchymal stromal cells, scattered throughout the fibrovascular connective tissue stroma containing areas of hemorrhage. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. Histologic features were correlated with the clinical. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. Central giant cell granuloma is a benign lesion of the jaws which is sometimes aggressive locally. Central giant cell granuloma is a benign intraosseous lesion of the jaws.

The central giant cell granuloma cgcg was first described by jaffe in 1953 as a giant cell reparative granuloma of the jaw bones. Central giant cell granuloma is a benign, intraosseous lesion of the jaws which exhibits a spectrum of clinical behavior ranging from nonaggressive to aggressive variants. The clinical behavior of central giant cell granuloma cgcg of the jaws is variable and difficult to predict. We report an unusual case of giant cell reparative granuloma gcrg arising in the nasal cavity of a 7yearold girl. Central giant cell granuloma, benign jaw tumor, molar, recurrent pericoronitis, multinucleated giant cells. Their clinical behavior8,29, prognostic factors and the histogenesis have been subject of several studies.

The true nature of these lesions is unknown but, as they are invariably destructive, the term reparative giant cell granuloma would appear to be inappropriate. Aggressive lesion can cause jaw to swell, and loosen teeth. The central giant cell granuloma is an uncommon lesion only seen in the toothbearing regions of the jaws, most commonly in the mandible and typically in the second and third decades. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. In spite of that, these questions remain unclear 11,16,23,26. Other treatments such as interferon ifn and calcitonin have been described. It is the most frequent giant cell lesion of the jaws, and originates from the connective tissue of the periosteum or from the periodontal. Giant cell reparative granuloma of the nasal cavity. In this retrospective study, records of patients with definitive diagnosis of cgcg were extracted from the. They result from a local inflammatory process, thought to be secondary to trauma.

Central giant cell granuloma cgcg is a localised benign condition of the jaws. Peripheral giant cell granuloma common tumor like growth in the oral cavity. Central giant cell granuloma aggresive of the jaws. The most common treatment is curettage,which has a high recurrence rate, particularly in more aggressive lesions. Central giant cell lesions granuloma dr yuranga weerakkody and assoc prof frank gaillard et al. Central giant cell granuloma cgcg of the jaws is a central osteolytic lesion characterized histologically by multinucleated giant cells in a background of ovoid to spindleshaped mesenchymal cells. Clinically and radiologically, a differentiation between aggressive and nonaggressive lesions can be made. Central giant cell granuloma was first described by jaffe in 1953.

Surgery was performed with the patient under general anaesthesia after nasal intubation, using a right preauricular approach. More recently these have also been identified in fibroosseous pseudotumour of the digits. Central giant cell granuloma cgcg is a benign intraosseous lesion of the jaws that is found predominantly in children and young adults. Central giant cell granuloma cgcg is an uncommon, benign, proliferative, and nonodontogenic lesion whose etiology is not defined. Central giant cell granuloma of the jaws regress with calcitonin therapy. A definite geographic variation has been observed in the frequency of odontogenic tumors and giant cell lesions of the jaws reported from different parts of the world. The concept at that time was that these lesions only seemed to occur in the jaws, they were found in the first two decades of life, more frequently in females approximately 2. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing benign jaw lesions. Central giant cell granuloma of the mandibular condyle.

Central giant cell lesions granulomas, also known as giant cell reparative cystsgranulomas, occurs almost exclusively in the mandible, although cases in the skull and maxilla have been reported. This case is a rare occurrence of central giant cell granuloma of the mandibular condyle. The case report is of a 30 year old male, who complained of a slowly expanding swelling in the maxilla in the left premolar region. Its etiology is unknown and its biological behavior is poorly understood. Giant cell lesions of the jaws were separated out from other jaw lesions by jaffe in 1953 when they were termed giant cell reparative granulomas. Central giant cell granuloma and fibrous dysplasia occurring in the same jaw is rarely reported in the literatures. Central giant cell granuloma and fibrous dysplasia occurring in the. The diagnosis and management of giant cell lesions of the.

It is twice as common in females and is more likely to occur before age 30. Central giant cell granuloma cgcg of the jaws and giant cell tumor gct of bone share a number of similarities and dissimilarities in respect of their histopathological, cytometric and immunohistochemical features. Giant cell granuloma an overview sciencedirect topics. Bilateral central giant cell granulomas of the mandible in an eight. Ct and mr imaging of giant cell granuloma of the craniofacial. Conventional management is surgical and consists of enucleation and curettage.

Pdf central giant cell granuloma aggresive of the jaws. The case report is of a 30 year old male, who complained of a slowly expanding swelling. Peripheral giant cell granuloma pgcg is an oral pathologic condition that appears in the mouth as an overgrowth of tissue due to irritation or trauma. As the distribution of immunostaining is identical to that observed in giant cell tumor of bone, our results support the possibility that central giant cell granuloma of the jaws and giant cell tumor of bone represent a similar disease process that clinically and histologically may have somewhat different features because of differences in the. Central giant cell granuloma is an uncommon benign intraosseus lesion of jaws. Considering the location, the highest number of recorded injuries reports the lower jaw as preferred site. The appearance is generally distinctive with multinucleated giant cells spread throughout the lesion but often focal in distribution around areas of possible hemorrhage figure 4. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. Central giant cell granuloma condyle mandible intraosseous abstract introduction. Central giant cell granuloma, fibrous dysplasia introduction central giant cell granuloma and fibrous dysplasia are relatively uncommon lesions1.

It has been described variably as a reactive, inflammatory, vascular, and endocrine process. Casereport munzenmayer j1, tapia p2, zeballos j2, martinez a3, compan a4, urra a5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection and reconstruction with fibula graft. Recurrent central giant cell granuloma in the mandible. Diagnosis of central giant cell granuloma is normally made histologically from an incisional biopsy. We report the results of the intralesional steroid injections for the management of central giant cell granuloma cgcg of the jaws.

This group of lesions includes central giant cell granuloma cgcg, giant cell. Clinical data and followup information of 26 patients with cgcg were analyzed. Pre and posttreatment pattern of clinical and radiographic presentation nalini aswath 1, pravda chidambaranathan 2. Frequently, a painless swelling that grows and expands rapidly is present. Case report giant cell tumor of the maxilla in an 8 year. Bilateral central giant cell granuloma of the mandibular. Seven cgcgs were treated with intralesional injection of corticosteroids. This article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy.

The etiology is unknown, but is thought to be a reactive process, possibly secondary to trauma or inflammation. The central giant cell granuloma cgcg is considered a benign, nonneoplastic lesion of bone found in a younger age group who are usually less than 30 years of age. The aim of this study was to determined demographic, clinical and radiographic features of central giant cell granuloma cgcg of the jaws, for the first time, in north east iran. Also called giant cell reparative granuloma central if intraosseous. Central giant cell granuloma cgcg is a benign, proliferative, intraosseous and nonodontogenic lesion of unknown etiology. Central giant cell granuloma of the jaws and giant cell tumor. Central giant cell granuloma of the jaw is considered a nonneoplastic lesion. Intralesional steroid treatment of central giant cell.

Case report giant cell tumor of the maxilla in an 8 year old boy. Traditional treatment has been local curettage, although aggressive subtypes. Management of central giant cell granuloma of the jaws. This condition is a slowgrowing, asymptomatic lesion that usually affects children and young adults, predominantly females. Central giant cell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings.

However, there are a few studies on these lesions, especially giant cell lesions, reported from india. The purpose of this study was to determine the ct characteristics and describe possible mr imaging features of gcg of the craniofacial bones. Clinically and radiographically difference between its nature. We present the case of a 60yearold woman with preauricular swelling, limitation of joint motion and pain on only the right side. A clinical, radiologic, and histopathologic study of 26 cases birgit kruseloesler, raihanatou ina diallo, christoph gaertner, karlludwig mischke, ulrich joos, johannes kleinheinz. The patients mother was also treated for an extensive giant cell granuloma of the maxilla.